Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Y-39983. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 7/20 | 1.00 |
| ▸ | ROCK1 known ✓ | Q13464 | 5/20 | 1.00 |
| ▸ | CIT | O14578 | 9/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 2/20 | 1.00 |
| ▸ | PRKACA | P17612 | 2/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 2/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 2/20 | 1.00 |
| ▸ | PKN2 | Q16513 | 2/20 | 1.00 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 1/20 | 1.00 |
| ▸ | PRKCB | P05771 | 1/20 | 1.00 |
| ▸ | PRKCA | P17252 | 1/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 1.00 |
| ▸ | MARK3 | P27448 | 1/20 | 1.00 |
| ▸ | BMPR1A | P36894 | 1/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 1.00 |
| ▸ | CLK1 | P49759 | 1/20 | 1.00 |
| ▸ | GSK3A | P49840 | 1/20 | 1.00 |
| ▸ | GSK3B | P49841 | 1/20 | 1.00 |
| ▸ | CDK9 | P50750 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Y-39983 SCHEMBL29431274 | 1.00 | CIT (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL226556 | 1.00 | CIT (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL25685649 | 1.00 | CIT (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL226557 | 1.00 | CIT (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL29816387 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL599801 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL599800 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL29666940 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL1927760 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA | |
| Y-39983 SCHEMBL1927761 | 0.99 | ROCK2 (1.00) | CITROCK2ROCK1PRKD3PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260014139-A1 | Femtosecond Laser Treatment Methods | PEYMAN GHOLAM A (US) | 2026-01-15 | — | — | US | disclosed |
| US-11648261-B2 | Method of treating, reducing, or alleviating a medical condition in a patient | PEYMAN GHOLAM A (US) | 2023-05-16 | — | — | US | disclosed |
| WO-2022211054-A1 | METHOD FOR PRODUCING OVARIAN SOMATIC CELL-LIKE CELLS, AND METHOD FOR INDUCING DIFFERENTIATION OF PRIMATE PLURIPOTENT STEM CELLS INTO OVARIAN SOMATIC CELL-LIKE CELLS | 国立大学法人京都大学 | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260014139-A1 | Femtosecond Laser Treatment Methods | GSK3B, GSK3A, CTNND1 | ROCK2 17/4885ROCK1 13/4885CIT 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.