Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 11/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.54 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.50 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29893296 | 0.77 | PARP1 (0.56) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL13082234 | 0.76 | TP53 (0.68) | TP53PARP1ALDH1A1CDC7PLK4 | |
| SCHEMBL8564331 | 0.76 | TP53 (0.68) | TP53PARP1CDC7PLK4AURKA | |
| SCHEMBL9415217 | 0.76 | TP53 (0.68) | TP53PARP1CDC7PLK4AURKA | |
| SCHEMBL8569594 | 0.76 | TP53 (0.68) | TP53PARP1MEN1KMT2ACDC7 | |
| SCHEMBL30902522 | 0.76 | TP53 (1.00) | TP53PARP1CDC7PLK4AURKA | |
| SCHEMBL4529420 | 0.76 | TP53 (0.68) | TP53PARP1PLA2G10MGAMPLA2G2A | |
| Hydrochloric Acid SCHEMBL9415725 | 0.75 | TP53 (0.66) | TP53PARP1ALDH1A1CDC7PLK4 | |
| SCHEMBL29673205 | 0.74 | PARP1 (1.00) | TP53PARP1ALDH1A1CDC7PLK4 | |
| SCHEMBL1133601 | 0.74 | PARP1 (1.00) | TP53PARP1ALDH1A1CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |