Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | PDE8A | O60658 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
| ▸ | PDE8B | O95263 | 1/20 | 0.49 |
| ▸ | PDE6A | P16499 | 1/20 | 0.49 |
| ▸ | PDE6G | P18545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038869 | 0.79 | POLB (0.58) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3495517 | 0.78 | GRIA1 (0.61) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29893237 | 0.77 | TP53 (0.61) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL30928050 | 0.75 | PARP1 (0.71) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3494657 | 0.75 | PARP1 (0.57) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL31377420 | 0.75 | PARP1 (0.57) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3493681 | 0.75 | GRIA1 (0.68) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8314522 | 0.74 | PTPRC (0.44) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL30273078 | 0.74 | PDE2A (0.69) | PARP1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2818529 | 0.74 | PDE2A (0.69) | PARP1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |