Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27188837 | 1.00 | GAA (0.41) | GAAROCK2MAPTGSK3BPDE4A | |
| SCHEMBL29896088 | 0.93 | POLB (0.44) | ROCK2MAPTGSK3BPOLBEPHX2 | |
| SCHEMBL23143270 | 0.93 | POLB (0.44) | ROCK2MAPTGSK3BPOLBEPHX2 | |
| SCHEMBL29896188 | 0.92 | SCN2A (0.41) | GAAROCK2MAPTGSK3BLMNA | |
| SCHEMBL27188884 | 0.92 | SCN2A (0.41) | GAAROCK2MAPTGSK3BLMNA | |
| SCHEMBL29896102 | 0.90 | AR (0.42) | ROCK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27188868 | 0.90 | AR (0.42) | ROCK2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27188857 | 0.88 | MAPT (0.41) | GAAROCK2MAPTGSK3BPDE4A | |
| SCHEMBL29896172 | 0.88 | MAPT (0.41) | GAAROCK2MAPTGSK3BPDE4A | |
| SCHEMBL29896142 | 0.88 | ROCK2 (0.39) | GAAROCK2LMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952344-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-04-09 | — | — | US | disclosed |
| US-20220340527-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340527-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | GRIN1, GRIN2A, GRIN2B | GAA 3884/4885ROCK2 4595/4885MAPT 210/4885 |
| US-11952344-B2 | Heterocyclic compound and use thereof | GRIN1, GRIN2A, GRIN2B | GAA 3884/4885ROCK2 4595/4885MAPT 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.