Isostrychnine

Isostrychnine

SCHEMBL29898321

O=C1CC=C2[C@H]3C[C@@H]4N(CC[C@@]45c4ccccc4N1[C@@H]25)C/C3=C/CO

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.43
HTR3A P46098 1/20 0.43
GLRA1 P23415 10/20 0.43
GLRB P48167 10/20 0.43
CYP3A4 P08684 2/20 0.43
SCN1A P35498 1/20 0.43
TAS2R46 P59540 1/20 0.43
SCN2A Q99250 1/20 0.43
SCN3A Q9NY46 1/20 0.43
TAS2R10 Q9NYW0 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CHRM2 P08172 1/20 0.40
CHRNA4 P43681 1/20 0.40
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isobrucine SCHEMBL31237253 0.83 CHRM1 (0.46) CHRNA7HTR3AGLRA1GLRBCYP3A4
SCHEMBL30553694 0.73 GLRA1 (0.56) CHRNA7HTR3AGLRA1GLRBCYP3A4
Bisnordihydrotoxiferine SCHEMBL29525342 0.68 CHRNA7 (0.56) CHRNA7HTR3AGLRA1GLRBCYP3A4
Strychnine SCHEMBL27614772 0.61 GLRA1 (0.91) GLRA1GLRBCYP3A4SCN1ATAS2R46
SCHEMBL29352385 0.60 CHRNA7 (0.44) CHRNA7HTR3AGLRA1GLRBCYP3A4
Strychnine SCHEMBL29889153 0.60 GLRA1 (0.90) GLRA1GLRBCYP3A4SCN1ATAS2R46
SCHEMBL28043707 0.60 GLRA1 (0.63) GLRA1GLRBCYP3A4SCN1ATAS2R46
Strychnine SCHEMBL12549549 0.60 GLRA1 (1.00) GLRA1GLRBCYP3A4SCN1ATAS2R46
Strychnine SCHEMBL93798 0.60 GLRA1 (1.00) GLRA1GLRBCYP3A4SCN1ATAS2R46
Strychnine SCHEMBL21985190 0.60 GLRA1 (1.00) GLRA1GLRBCYP3A4SCN1ATAS2R46

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 WO disclosed
CN-115990206-B Nux vomica processing machine 重庆医药高等专科学校 2023-10-24 CN disclosed
CN-116026116-A Nux vomica drying device 重庆医药高等专科学校 2023-04-28 CN disclosed
CN-115990206-A Nux vomica processing machine 重庆医药高等专科学校 2023-04-21 CN disclosed
CN-114917272-B Baking and processing technology of nux vomica 重庆医药高等专科学校 2023-04-14 CN disclosed
CN-115921045-A Nux vomica reducing mechanism 重庆医药高等专科学校 2023-04-07 CN disclosed
CN-114917272-A Baking and processing technology of nux vomica 重庆医药高等专科学校 2022-08-19 CN disclosed