Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 4/20 | 0.46 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 2/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23143503 | 1.00 | PDE3B (0.50) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL29899591 | 0.84 | GRIA1 (0.52) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL16322090 | 0.84 | GRIA1 (0.52) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL26463416 | 0.81 | GRIA1 (0.52) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL30494415 | 0.81 | GRIA1 (0.52) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL10710464 | 0.80 | GRIA1 (0.54) | KDM1ATDP2CMA1AHRCRBN | |
| SCHEMBL6744175 | 0.79 | PDE3B (0.76) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL29850050 | 0.79 | PDE3B (0.76) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL3659028 | 0.76 | CYP11B1 (0.79) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL29899622 | 0.76 | CYP11B1 (0.79) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929670-A | Therapeutic compounds and methods of use thereof | 新加坡科技研究局 | 2022-08-19 | — | — | CN | disclosed |