Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 3/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.48 |
| ▸ | TDP2 | O95551 | 4/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | FABP7 | O15540 | 2/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10712809 | 0.88 | GRIA1 (0.69) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL22904161 | 0.84 | TDP2 (0.60) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL5782680 | 0.82 | GRIA1 (0.78) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL4408889 | 0.80 | TDP2 (0.65) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL23143503 | 0.80 | PDE3B (0.50) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL29899561 | 0.80 | PDE3B (0.50) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL26932401 | 0.80 | BRD4 (0.49) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL4406924 | 0.78 | CHEK1 (0.58) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL10713146 | 0.77 | TDP2 (0.69) | GRIA1CACNG8BRD4CREBBPAHR | |
| SCHEMBL30296573 | 0.75 | AHR (0.49) | GRIA1CACNG8BRD4CREBBPAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |