Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609259 | 1.00 | ERN1 (0.59) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL28855366 | 1.00 | ERN1 (0.59) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL21822700 | 0.88 | ALDH1A1 (0.57) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6703657 | 0.85 | ERN1 (0.51) | ERN1SMN1; SMN2MAPTL3MBTL1NPC1 | |
| SCHEMBL1067302 | 0.85 | ALDH1A1 (0.58) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17513671 | 0.85 | ERN1 (0.55) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16096378 | 0.84 | ERN1 (0.51) | ERN1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL4596442 | 0.84 | SMN1; SMN2 (0.60) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20563703 | 0.84 | SMN1; SMN2 (0.60) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20982624 | 0.84 | ERN1 (0.59) | ERN1HPGDSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110776-A1 | NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2023-01-04 | — | — | EP | disclosed |
| CN-115151538-A | Macrocyclic compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-10-04 | — | — | CN | disclosed |