SCHEMBL29901136

SCHEMBL29901136

O=C(O)Nc1ccc(Br)c2cc[nH]c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 3/20 0.39
PTPRC P08575 1/20 0.38
PTPN2 P17706 1/20 0.38
PTPN1 P18031 1/20 0.38
PTPRB P23467 1/20 0.38
PTPRE P23469 1/20 0.38
PTPN6 P29350 1/20 0.38
PRKCI P41743 1/20 0.36
EPHX1 P07099 2/20 0.35
PARP1 P09874 4/20 0.35
AHR P35869 1/20 0.34
KMT2A Q03164 2/20 0.33
BTK Q06187 2/20 0.33
TP53 P04637 1/20 0.33
GOT1 P17174 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31488142 0.85 RXFP1 (0.57) RXFP1PRKCIEPHX1BTKKDM4E
SCHEMBL14746763 0.81 JAK2 (0.46) RXFP1PTPRCPTPN2PTPN1PTPRB
SCHEMBL29926665 0.81 JAK2 (0.46) RXFP1PTPRCPTPN2PTPN1PTPRB
SCHEMBL22531302 0.80 JAK2 (0.40) PTPRCPTPN2PTPN1PTPRBPTPRE
SCHEMBL29764491 0.80 JAK2 (0.40) PTPRCPTPN2PTPN1PTPRBPTPRE
SCHEMBL2768424 0.78 AAK1 (0.39) RXFP1KMT2AMEN1MAPTNPC1
SCHEMBL30456361 0.74 KEAP1 (0.49) PTPN1PRKCIPARP1AHRBTK
SCHEMBL2382490 0.74 KEAP1 (0.49) PTPN1PRKCIPARP1AHRBTK
SCHEMBL1978079 0.72 RXFP1 (0.71) RXFP1EPHX1KMT2ATP53KDM4E
SCHEMBL29556631 0.71 AHR (0.48) PRKCIPARP1AHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240174648-A1 Small Molecule Compound TECHNODERMA MEDICINES INC. (CN) 2024-05-30 US disclosed
EP-4050009-A1 SMALL MOLECULE COMPOUND Technoderma Medicines Pte Ltd (CN) 2022-08-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240174648-A1 Small Molecule Compound JAK1, JAK2, TYK2 RXFP1 581/4885PTPRC 538/4885PTPN2 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.