Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 17/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23706884 | 1.00 | ATF4 (0.53) | ATF4HDAC8ANO1GPR119 | |
| SCHEMBL21389995 | 0.91 | ATF4 (0.59) | ATF4HDAC8GPR119 | |
| SCHEMBL21384497 | 0.87 | ATF4 (0.56) | ATF4HDAC8 | |
| SCHEMBL21384496 | 0.87 | ATF4 (0.56) | ATF4HDAC8 | |
| SCHEMBL21390157 | 0.87 | ATF4 (0.56) | ATF4HDAC8 | |
| SCHEMBL23294677 | 0.87 | ATF4 (0.56) | ATF4HDAC8 | |
| SCHEMBL21390155 | 0.87 | ATF4 (0.56) | ATF4HDAC8 | |
| SCHEMBL23702460 | 0.85 | ATF4 (0.59) | ATF4 | |
| SCHEMBL23702461 | 0.85 | ATF4 (0.59) | ATF4 | |
| SCHEMBL23702462 | 0.85 | ATF4 (0.59) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114980894-B | Modulators of integrated stress response pathways | 埃沃特克国际有限责任公司 | 2024-10-18 | — | — | CN | disclosed |
| EP-4096665-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2022-12-07 | — | — | EP | disclosed |
| CN-114980894-A | Modulators of integrated stress response pathways | 埃沃特克国际有限责任公司 | 2022-08-30 | — | — | CN | disclosed |