Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 2/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.77 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.75 |
| ▸ | TTPA | P49638 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628454 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| SCHEMBL21999363 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| (+)-Alpha-Tocopheryl Succinate SCHEMBL17749239 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| (+)-Alpha-Tocopheryl Succinate SCHEMBL29409614 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| (+)-Alpha-Tocopheryl Succinate SCHEMBL12628147 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| (+)-Alpha-Tocopheryl Succinate SCHEMBL2162349 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| (+)-Alpha-Tocopheryl Succinate SCHEMBL134422 | 1.00 | GSTO1 (1.00) | GSTO1PTPN1MEN1KMT2APDE4A | |
| SCHEMBL13309644 | 0.96 | GSTO1 (0.93) | GSTO1PTPN1MEN1KMT2APDE4A | |
| SCHEMBL12535829 | 0.96 | GSTO1 (0.93) | GSTO1PTPN1MEN1KMT2APDE4A | |
| SCHEMBL22199470 | 0.96 | GSTO1 (0.93) | GSTO1PTPN1MEN1KMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076405-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING N-[1-(5-CYANO-PYRIDIN-2-YLMETHYL)-1H-PYRAZOL-3-YL]-2-[4-(1-TRIFLUOROMETHYL-CYCLOPROPYL)-PHENYL]-ACETAMIDE | Idorsia Pharmaceuticals Ltd (CH) | 2022-10-26 | — | — | EP | disclosed |