Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906518 | 1.00 | EGFR (0.51) | EGFRALKPDGFRBPDGFRAROS1 | |
| SCHEMBL26906770 | 0.87 | EGFR (0.49) | EGFRPDGFRBPDGFRA | |
| SCHEMBL26906735 | 0.86 | ALK (0.58) | EGFRALKROS1 | |
| SCHEMBL26906985 | 0.86 | EGFR (0.51) | EGFRALK | |
| SCHEMBL30692634 | 0.84 | EGFR (0.58) | EGFRALKROS1FLT3 | |
| SCHEMBL26906712 | 0.84 | EGFR (0.58) | EGFRALKROS1FLT3 | |
| SCHEMBL26906691 | 0.83 | ROS1 (0.58) | EGFRALKROS1 | |
| SCHEMBL26906487 | 0.82 | EGFR (0.65) | EGFRALKPDGFRBPDGFRAROS1 | |
| SCHEMBL29904688 | 0.80 | ROS1 (0.56) | EGFRALKROS1 | |
| SCHEMBL26906877 | 0.80 | ROS1 (0.56) | EGFRALKROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |