SCHEMBL299048

SCHEMBL299048

c1ccc(-c2csc(-c3ccc(-c4ccccn4)s3)n2)cc1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.58
KDM4E B2RXH2 7/20 0.58
NPC1 O15118 5/20 0.58
MAPT P10636 3/20 0.58
GLA P06280 1/20 0.58
KMT2A Q03164 3/20 0.55
AR P10275 1/20 0.55
CYP19A1 P11511 6/20 0.54
ALDH1A1 P00352 4/20 0.51
MAPK1 P28482 1/20 0.51
SREBF2 Q12772 2/20 0.49
MEN1 O00255 2/20 0.48
PKM P14618 1/20 0.48
GFER P55789 1/20 0.48
HSD17B10 Q99714 1/20 0.48
KDM4C Q9H3R0 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
PDE10A Q9Y233 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17014755 0.85 RAB9A (0.66) RAB9AKDM4ENPC1MAPTKMT2A
SCHEMBL1741734 0.79 CYP19A1 (0.72) RAB9AKDM4ENPC1MAPTKMT2A
SCHEMBL4658811 0.78 KDM4E (0.79) RAB9AKDM4ENPC1MAPTGLA
SCHEMBL2387268 0.78 KDM4E (0.54) RAB9AKDM4ENPC1MAPTKMT2A
SCHEMBL298722 0.77 KDM4E (0.54) RAB9AKDM4ENPC1MAPTGLA
SCHEMBL3069800 0.76 KDM4E (1.00) RAB9AKDM4ENPC1MAPTGLA
SCHEMBL2781370 0.74 KDM4E (0.85) RAB9AKDM4ENPC1MAPTKMT2A
SCHEMBL28857293 0.74 KDM4E (0.95) RAB9AKDM4ENPC1MAPTGLA
SCHEMBL23743236 0.74 CYP19A1 (0.72) RAB9AKDM4ENPC1MAPTKMT2A
SCHEMBL4436213 0.74 SREBF2 (0.67) RAB9AKDM4ENPC1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427447-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION Pike Pharma GmbH (CH) 2012-03-14 EP claimed
WO-2010128163-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION PIKE PHARMA GMBH (CH) 2010-11-11 WO claimed
EP-2427447-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION Pike Pharma GmbH (CH) 2012-03-14 EP disclosed
WO-2010128163-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION PIKE PHARMA GMBH (CH) 2010-11-11 WO disclosed