Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754350 | 1.00 | KLKB1 (0.62) | KLKB1NOTUMCYP11B2MAPT | |
| SCHEMBL23754054 | 0.89 | KLKB1 (0.60) | KLKB1NOTUM | |
| SCHEMBL23754015 | 0.88 | KLKB1 (0.48) | KLKB1NOTUM | |
| SCHEMBL23843175 | 0.87 | KLKB1 (0.65) | KLKB1 | |
| SCHEMBL23754079 | 0.87 | KLKB1 (0.65) | KLKB1 | |
| SCHEMBL23754039 | 0.87 | KLKB1 (0.47) | KLKB1NOTUMMAPT | |
| SCHEMBL23754014 | 0.87 | NOTUM (0.49) | KLKB1NOTUMMAPT | |
| SCHEMBL23769720 | 0.84 | KLKB1 (0.49) | KLKB1NOTUMMAPT | |
| SCHEMBL23754078 | 0.81 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL29906544 | 0.81 | KLKB1 (0.46) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120287-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-116120287-A | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2023-05-16 | — | — | CN | disclosed |
| EP-4103562-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2022-12-21 | — | — | EP | disclosed |
| CN-115052873-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-13 | — | — | CN | disclosed |