Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23769721 | 0.88 | NOTUM (0.41) | KLKB1NOTUMMAPTPRKD3MAP4K4 | |
| SCHEMBL23754054 | 0.87 | KLKB1 (0.60) | KLKB1NOTUMP2RY12 | |
| SCHEMBL23754350 | 0.84 | KLKB1 (0.62) | KLKB1NOTUMMAPT | |
| SCHEMBL29906552 | 0.84 | KLKB1 (0.62) | KLKB1NOTUMMAPT | |
| SCHEMBL28986729 | 0.78 | NOTUM (0.53) | NOTUMUSP30 | |
| SCHEMBL29906606 | 0.74 | KLKB1 (0.46) | KLKB1NOTUMMAPTKDM4EALDH1A1 | |
| SCHEMBL23754033 | 0.74 | KLKB1 (0.46) | KLKB1NOTUMMAPTKDM4EALDH1A1 | |
| SCHEMBL29906588 | 0.73 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL23754316 | 0.73 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL23753990 | 0.73 | KLKB1 (0.45) | KLKB1NOTUMMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |