Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29859847 | 0.79 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2GFERCYP1A2CYP2C19 | |
| SCHEMBL2136361 | 0.74 | HTT (0.49) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL16597986 | 0.73 | SMN1; SMN2 (0.67) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL2134373 | 0.71 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL26921832 | 0.70 | GFER (0.67) | ALDH1A1SMN1; SMN2GFERCYP1A2CYP2C19 | |
| SCHEMBL29834783 | 0.70 | GFER (0.67) | ALDH1A1SMN1; SMN2GFERCYP1A2CYP2C19 | |
| SCHEMBL23168014 | 0.70 | TRPV3 (0.52) | NPSR1TRPV3 | |
| SCHEMBL30880806 | 0.69 | KDM4E (0.52) | ALDH1A1SMN1; SMN2GFERMEN1KMT2A | |
| SCHEMBL3462236 | 0.69 | SMN1; SMN2 (0.80) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL2136709 | 0.69 | CHRM3 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | claimed |
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |