Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22552123 | 1.00 | ADORA2A (0.67) | ADORA2AADORA1ADORA2BMAPK1ROCK2 | |
| SCHEMBL22551871 | 0.91 | ADORA2A (0.63) | ADORA2AADORA1ADORA2BMAPK1ROCK2 | |
| SCHEMBL29906680 | 0.91 | ADORA2A (0.63) | ADORA2AADORA1ADORA2BMAPK1ROCK2 | |
| SCHEMBL21730250 | 0.89 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BMAPK1ROCK2 | |
| SCHEMBL21730385 | 0.89 | ADORA2A (0.67) | ADORA2AADORA1ADORA2BROCK2ROCK1 | |
| SCHEMBL29906702 | 0.87 | ADORA2A (0.70) | ADORA2AADORA1ADORA2BROCK2ROCK1 | |
| SCHEMBL21730174 | 0.87 | ADORA2A (0.70) | ADORA2AADORA1ADORA2BROCK2ROCK1 | |
| SCHEMBL29906692 | 0.87 | ADORA2A (0.83) | ADORA2AADORA1ADORA2B | |
| SCHEMBL22551955 | 0.87 | ADORA2A (0.83) | ADORA2AADORA1ADORA2B | |
| SCHEMBL22551834 | 0.86 | ADORA2A (0.73) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | claimed |
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| US-11571420-B2 | Pyrazine compounds and uses thereof | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-02-07 | — | — | US | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11571420-B2 | Pyrazine compounds and uses thereof | ADORA2A, ADORA2B, ADORA1 | ADORA2A 1/4885ADORA1 3/4885ADORA2B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.