Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 3/20 | 0.38 |
| ▸ | GRK2 | P25098 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23210923 | 1.00 | MAP4K3 (0.43) | MAP4K3METALKKCNH2GRK5 | |
| SCHEMBL23210972 | 0.93 | MAP4K3 (0.35) | MAP4K3METFGFR1FGFR2FGFR3 | |
| SCHEMBL29907149 | 0.93 | MAP4K3 (0.35) | MAP4K3METFGFR1FGFR2FGFR3 | |
| SCHEMBL29907113 | 0.89 | MAP4K3 (0.45) | MAP4K3METALKKCNH2GRK5 | |
| SCHEMBL23211009 | 0.89 | MAP4K3 (0.45) | MAP4K3METALKKCNH2GRK5 | |
| SCHEMBL23210911 | 0.85 | BUB1 (0.34) | ALK | |
| SCHEMBL29907158 | 0.85 | BUB1 (0.34) | ALK | |
| SCHEMBL29907068 | 0.83 | ROCK2 (0.37) | GRK2 | |
| SCHEMBL23211088 | 0.83 | ROCK2 (0.37) | GRK2 | |
| SCHEMBL23236622 | 0.82 | MAP4K3 (0.38) | MAP4K3METALKGRK5NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |