Sugi Predict

Sugi Predict / Compounds / SCHEMBL29907137

SCHEMBL29907137

SCHEMBL29907137

COc1ccc(Cn2nc(-c3ccc(C4CN(C(=O)OC(C)(C)C)C4)nc3)c3nc(-c4cccc5c4CCC5)c(OC)cc32)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ CRHBP P24387 1/20 0.35
▸ CRHR2 Q13324 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ MERTK Q12866 2/20 0.35
▸ AXL P30530 1/20 0.35
▸ PTGIR P43119 2/20 0.34
▸ PTGDR Q13258 1/20 0.34
▸ EHMT2 Q96KQ7 1/20 0.33
▸ STAT3 P40763 1/20 0.33
▸ PDE4A P27815 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ PDE4C Q08493 1/20 0.33
▸ PDE4D Q08499 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23210854 1.00 HTT (0.35) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL23211056 0.95 KDM4E (0.39) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL29907087 0.95 KDM4E (0.39) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL29907146 0.94 KDM4E (0.41) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL23210793 0.94 KDM4E (0.41) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL23211007 0.92 PDE4A (0.36) HTTMEN1KMT2APTGIRPTGDR
SCHEMBL30308828 0.90 GYS1 (0.35) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL30308914 0.90 GYS1 (0.37) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL30308771 0.89 GYS1 (0.36) HTTKDM4EALDH1A1HPGDMEN1
SCHEMBL23264043 0.89 PTGIR (0.32) HTTMEN1KMT2APTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2025-02-20 — — US disclosed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 — — US disclosed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 — — US disclosed
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2023-03-21 — — US disclosed
EP-4045151-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS Incyte Corporation (US) 2022-08-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 HTT 1868/4885KDM4E 713/4885ALDH1A1 559/4885
US-20250057852-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 HTT 1868/4885KDM4E 713/4885ALDH1A1 559/4885
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 HTT 1868/4885KDM4E 713/4885ALDH1A1 559/4885
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 HTT 1868/4885KDM4E 713/4885ALDH1A1 559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.