Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.41 |
| ▸ | BUB1 | O43683 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23210908 | 1.00 | ROCK2 (0.41) | ROCK2BUB1AURKAGRK2ROCK1 | |
| SCHEMBL23211088 | 0.86 | ROCK2 (0.37) | ROCK2BUB1AURKAGRK2ROCK1 | |
| SCHEMBL29907068 | 0.86 | ROCK2 (0.37) | ROCK2BUB1AURKAGRK2ROCK1 | |
| SCHEMBL29907070 | 0.85 | BUB1 (0.42) | BUB1 | |
| SCHEMBL23210943 | 0.85 | BUB1 (0.42) | BUB1 | |
| SCHEMBL23210986 | 0.83 | BUB1 (0.39) | BUB1 | |
| SCHEMBL29907069 | 0.83 | BUB1 (0.39) | BUB1 | |
| SCHEMBL23210853 | 0.82 | FGFR1 (0.37) | BUB1 | |
| SCHEMBL29907024 | 0.82 | FGFR1 (0.37) | BUB1 | |
| SCHEMBL29008859 | 0.81 | BUB1 (0.37) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |