Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 3/20 | 0.33 |
| ▸ | ADA | P00813 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23211069 | 1.00 | FGFR1 (0.35) | FGFR1SRCCYP19A1NQO2ALDH1A1 | |
| SCHEMBL23211080 | 0.91 | ACSS2 (0.33) | ACSS2 | |
| SCHEMBL23210728 | 0.86 | ACSS2 (0.39) | MAPTACSS2POLBSMN1; SMN2LMNA | |
| SCHEMBL23236623 | 0.86 | — | — | |
| SCHEMBL23211141 | 0.84 | GRIN1 (0.32) | — | |
| SCHEMBL29907123 | 0.77 | CTSA (0.37) | ALDH1A1MAPTPDE10ASMN1; SMN2GAA | |
| SCHEMBL23211040 | 0.77 | CTSA (0.37) | ALDH1A1MAPTPDE10ASMN1; SMN2GAA | |
| SCHEMBL19949833 | 0.77 | NPSR1 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL23210808 | 0.76 | PDE2A (0.34) | ALDH1A1ACSS2PDE10ASMN1; SMN2GAA | |
| SCHEMBL29907029 | 0.76 | PDE2A (0.34) | ALDH1A1ACSS2PDE10ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |