Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27147455 | 1.00 | LRRK2 (0.45) | LRRK2DRD1HPGDSMN1; SMN2EGLN1 | |
| SCHEMBL18520013 | 0.85 | DRD1 (0.45) | DRD1HPGDSMN1; SMN2EGLN1ALDH1A1 | |
| SCHEMBL986616 | 0.81 | DRD1 (0.47) | LRRK2DRD1EGLN1MMP12ALDH1A1 | |
| SCHEMBL29424879 | 0.81 | DRD1 (0.47) | LRRK2DRD1EGLN1MMP12ALDH1A1 | |
| SCHEMBL27147106 | 0.81 | DRD1 (0.42) | LRRK2DRD1EGLN1MMP12ALDH1A1 | |
| SCHEMBL31588225 | 0.79 | DRD1 (0.45) | LRRK2DRD1EGLN1MMP12ALDH1A1 | |
| SCHEMBL18490452 | 0.77 | CDC7 (0.49) | DRD1HPGDEGLN1ALDH1A1CDK1 | |
| Alcohol SCHEMBL4794104 | 0.76 | DRD1 (0.49) | DRD1HPGDEGLN1ALDH1A1RPS6KA5 | |
| SCHEMBL842410 | 0.72 | DRD1 (0.52) | DRD1HPGDEGLN1MMP12ALDH1A1 | |
| SCHEMBL12894974 | 0.71 | DRD2 (0.54) | HPGDSMN1; SMN2ALDH1A1PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |