Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SLC9A5 | Q14940 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22551815 | 1.00 | ADORA2A (0.36) | ADORA2ARAB9AMAPTNPC1TDP1 | |
| SCHEMBL17778186 | 0.89 | ADORA2A (0.39) | ADORA2ARAB9AMAPTNPC1TDP1 | |
| SCHEMBL21555702 | 0.76 | ADORA2A (0.49) | ADORA2ARAB9ANPC1TDP1MEN1 | |
| SCHEMBL21555703 | 0.76 | TDP1 (0.36) | ADORA2ARAB9AMAPTNPC1TDP1 | |
| SCHEMBL17768969 | 0.75 | TDP1 (0.38) | ADORA2ARAB9ANPC1TDP1MEN1 | |
| SCHEMBL22552131 | 0.74 | ADORA2A (0.51) | ADORA2AMAPTNPC1TDP1SMN1; SMN2 | |
| SCHEMBL29907526 | 0.74 | ADORA2A (0.51) | ADORA2AMAPTNPC1TDP1SMN1; SMN2 | |
| SCHEMBL17768753 | 0.73 | CNR1 (0.49) | ADORA2AMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL17768614 | 0.73 | ADORA2A (0.45) | ADORA2ASMN1; SMN2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL22552073 | 0.73 | HTT (0.42) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |