Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27960788 | 0.80 | GRM1 (0.49) | CYP2D6GRM1CYP3A4ELANE | |
| SCHEMBL1514381 | 0.80 | GRM1 (0.47) | CYP2D6GRM1CYP3A4PIM1PIM3 | |
| SCHEMBL12835720 | 0.80 | GRM1 (0.47) | CYP2D6GRM1CYP3A4PIM1PIM3 | |
| SCHEMBL30607671 | 0.79 | KDM4E (0.55) | GRM1JAK3JAK2ELANEPDE10A | |
| SCHEMBL26111523 | 0.79 | KDM4E (0.55) | GRM1JAK3JAK2ELANEPDE10A | |
| Hydrochloric Acid SCHEMBL1514298 | 0.78 | GRM1 (0.46) | CYP2D6GRM1CYP3A4PIM1PIM3 | |
| SCHEMBL21722525 | 0.74 | GRM1 (0.45) | CYP2D6GRM1CYP3A4 | |
| SCHEMBL21722473 | 0.74 | KDM4E (0.47) | CYP2D6GRM1CYP3A4 | |
| SCHEMBL30307674 | 0.74 | KDM4E (0.47) | CYP2D6GRM1CYP3A4 | |
| SCHEMBL30607573 | 0.73 | KDM4E (0.61) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |