Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21730350 | 1.00 | LMNA (0.51) | LMNAPKMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22551809 | 0.86 | KDM4E (0.46) | LMNAPKMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29907784 | 0.86 | KDM4E (0.46) | LMNAPKMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22551772 | 0.86 | KDM4E (0.40) | LMNAPKMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5425548 | 0.86 | SMN1; SMN2 (0.52) | PKMKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL21730335 | 0.85 | ATR (0.41) | PKMKDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22579104 | 0.85 | MAPT (0.40) | LMNAPKMKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21722384 | 0.84 | PLAU (0.43) | LMNAKDM4EALDH1A1IKBKBADORA2A | |
| SCHEMBL21730378 | 0.84 | TDP1 (0.44) | ADORA2APLAUDHODH | |
| SCHEMBL29907506 | 0.84 | TDP1 (0.44) | ADORA2APLAUDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |