Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22552045 | 1.00 | ADORA2A (0.47) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL22579112 | 0.89 | ADORA2A (0.49) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL4584433 | 0.83 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL29907718 | 0.82 | ADORA2A (0.60) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL22552057 | 0.82 | ADORA2A (0.60) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL4584998 | 0.82 | ADORA2A (0.57) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL29987316 | 0.81 | ADORA2A (0.65) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4585883 | 0.81 | ADORA2A (0.65) | ADORA2AADORA1ADORA2B | |
| SCHEMBL22579156 | 0.81 | ADORA2A (0.48) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL22551818 | 0.80 | ADORA2A (0.78) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |