Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21730231 | 1.00 | NAMPT (0.47) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL12663061 | 0.88 | NAMPT (0.44) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL16829010 | 0.84 | NAMPT (0.45) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL1631864 | 0.83 | ADORA2A (0.48) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL30890544 | 0.83 | CHRM2 (0.47) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL20283080 | 0.83 | SCN9A (0.41) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL29509454 | 0.83 | SCN9A (0.41) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL4664237 | 0.83 | NAMPT (0.44) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL1631862 | 0.82 | NAMPT (0.46) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 | |
| SCHEMBL18764702 | 0.82 | NAMPT (0.46) | NAMPTL3MBTL1CYP3A4KDM4AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |