Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16829010 | 0.88 | NAMPT (0.45) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL12578946 | 0.85 | ATR (0.47) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL21730231 | 0.83 | NAMPT (0.47) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL29907709 | 0.83 | NAMPT (0.47) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL15804093 | 0.82 | NAMPT (0.46) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL12663061 | 0.82 | NAMPT (0.44) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL35210561 | 0.81 | NAMPT (0.46) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL17018589 | 0.81 | NAMPT (0.46) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL4777327 | 0.81 | KCNA5 (0.41) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E | |
| SCHEMBL23541505 | 0.80 | NAMPT (0.45) | NAMPTKCNA5CYP3A4L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924561-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | Eli Lilly & Company (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028083-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |