Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.42 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22552019 | 1.00 | ADORA2A (0.52) | ADORA2AADORA1BRD4ADORA2BUSP8 | |
| SCHEMBL4585480 | 0.89 | USP8 (0.48) | ADORA2AADORA1BRD4ADORA2BUSP8 | |
| SCHEMBL4584757 | 0.86 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BUSP8ADORA3 | |
| SCHEMBL14545408 | 0.83 | ERBB2 (0.53) | ADORA2AADORA1ADORA2BUSP8ERBB2 | |
| SCHEMBL4584217 | 0.82 | USP8 (0.40) | ADORA2AADORA1BRD4ADORA2BUSP8 | |
| SCHEMBL4585557 | 0.81 | ADORA2A (0.65) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL21722596 | 0.79 | ADORA2A (0.63) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL28949046 | 0.79 | KDM4E (0.47) | ADORA2AADORA1ADORA2BUSP8ERBB2 | |
| SCHEMBL21722354 | 0.78 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BADORA3ERBB2 | |
| SCHEMBL29987316 | 0.78 | ADORA2A (0.65) | ADORA2AADORA1BRD4ADORA2BCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |