Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585883 | 0.90 | ADORA2A (0.65) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL29987316 | 0.90 | ADORA2A (0.65) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL4583598 | 0.89 | ADORA2A (0.55) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4584010 | 0.86 | ADORA2A (0.64) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4585704 | 0.82 | ADORA2A (0.46) | ADORA2AADORA1BRD4ADORA2B | |
| SCHEMBL4585460 | 0.81 | ADORA2A (0.57) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4584950 | 0.81 | ADORA2A (0.49) | ADORA2AADORA1ADORA2B | |
| SCHEMBL29907736 | 0.81 | ADORA2A (0.52) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL22552019 | 0.81 | ADORA2A (0.52) | ADORA2AADORA1BRD4ADORA2BCREBBP | |
| SCHEMBL4584433 | 0.80 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407961-B2 | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2008-08-05 | — | — | US | disclosed |
| CN-1871231-A | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC (JP) | 2006-11-29 | — | — | CN | disclosed |
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113387-A1 | Pyrazine derivatives and pharmaceutical use thereof | ADORA2A, P2RX5, ADORA1 | ADORA2A 1/4885ADORA1 3/4885BRD4 3462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.