Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22552073 | 1.00 | HTT (0.42) | HTTSMN1; SMN2CTDSP1KMT2AMEN1 | |
| SCHEMBL29906699 | 0.84 | HTT (0.38) | HTTSMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL22552070 | 0.84 | HTT (0.38) | HTTSMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL21722411 | 0.82 | ADORA2A (0.47) | HTTSMN1; SMN2CTDSP1LMNAATR | |
| SCHEMBL29907526 | 0.75 | ADORA2A (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL22552131 | 0.75 | ADORA2A (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL22551815 | 0.73 | ADORA2A (0.36) | SMN1; SMN2KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL29907633 | 0.73 | ADORA2A (0.36) | SMN1; SMN2KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL17778186 | 0.73 | ADORA2A (0.39) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17768753 | 0.71 | CNR1 (0.49) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |