Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | NPC1 | O15118 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28478834 | 1.00 | STAT3 (1.00) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL30892625 | 0.90 | STAT3 (0.82) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL159312 | 0.90 | STAT3 (0.82) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL10252930 | 0.89 | STAT3 (0.80) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL375898 | 0.86 | STAT3 (0.76) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2681128 | 0.86 | STAT3 (1.00) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL28573489 | 0.84 | STAT3 (1.00) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL29908288 | 0.84 | STAT3 (1.00) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL29908283 | 0.84 | STAT3 (0.72) | STAT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL28576662 | 0.84 | STAT3 (0.72) | STAT3RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585309-A | Application of nitazoxanide and derivatives in preparation of polymyxin antibacterial synergists, pharmaceutical composition and sterilization method | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 2023-08-15 | — | — | CN | claimed |
| CN-116585309-A | Application of nitazoxanide and derivatives in preparation of polymyxin antibacterial synergists, pharmaceutical composition and sterilization method | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 2023-08-15 | — | — | CN | disclosed |
| CN-116456980-A | Application of thiazole compounds in preparation of medicines for treating and preventing cancers | 北京大学 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022206084-A1 | USE OF THIAZOLE COMPOUND IN PREPARATION OF DRUG FOR TREATING AND PREVENTING CANCER | 北京大学 | 2022-10-06 | — | — | WO | disclosed |