Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328279 | 0.84 | MAPK1 (0.55) | PARP1MAPK1L3MBTL1POLBTHRB | |
| SCHEMBL1161158 | 0.83 | TYK2 (0.50) | MAPK1ALDH1A1METAXLTYRO3 | |
| Hydrochloric Acid SCHEMBL23071632 | 0.82 | TYK2 (0.49) | MAPK1ALDH1A1METAXLTYRO3 | |
| SCHEMBL5510400 | 0.82 | ALDH1A1 (0.51) | PARP1MAPK1ALDH1A1LMNANOTUM | |
| SCHEMBL29815065 | 0.82 | ALDH1A1 (0.51) | PARP1MAPK1ALDH1A1LMNANOTUM | |
| SCHEMBL1396731 | 0.81 | MAPK1 (0.58) | PARP1MAPK1ALDH1A1L3MBTL1AXL | |
| SCHEMBL29908864 | 0.80 | KDM4E (0.51) | PARP1ALDH1A1MGLLKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29908833 | 0.80 | MAPK1 (0.56) | PARP1MAPK1ALDH1A1L3MBTL1AXL | |
| SCHEMBL16812361 | 0.78 | POLB (0.47) | ALDH1A1L3MBTL1FAAHMGLLPOLB | |
| SCHEMBL15328201 | 0.77 | MAPK1 (0.47) | PARP1MAPK1ALDH1A1ABL1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111295386-B | Thienopyridine derivatives and pharmaceutical compositions containing the same | 伟迈可生物有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-116685324-A | Pharmaceutical composition for preventing or treating pancreatic cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116390729-A | Pharmaceutical composition for preventing or treating non-small cell lung cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-115916210-A | Pharmaceutical composition for preventing or treating small cell lung cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115209900-A | Pharmaceutical composition for preventing or treating cancer in which KRAS mutation and activated RON are present | 伟迈可生物有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115003307-A | Pharmaceutical composition for preventing or treating cancers associated with KRAS mutations | 伟迈可生物有限公司 | 2022-09-02 | — | — | CN | disclosed |