Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29908945 | 0.90 | HDAC8 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29908969 | 0.83 | HDAC8 (0.57) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24881075 | 0.82 | HDAC8 (0.63) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL31522340 | 0.82 | HDAC8 (0.67) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1744913 | 0.80 | HDAC8 (0.61) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL557990 | 0.79 | HDAC8 (0.60) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29908950 | 0.78 | HDAC8 (0.51) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24880999 | 0.78 | HDAC8 (0.61) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| Sebacic Acid SCHEMBL3905690 | 0.77 | HDAC8 (0.57) | HDAC8HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30207564 | 0.76 | HPGD (0.57) | HDAC8HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12569563-B2 | Selective HDAC6 degraders and methods of use thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2026-03-10 | — | — | US | disclosed |
| US-20230011665-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-01-12 | — | — | US | disclosed |
| EP-4054607-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230011665-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | HDAC6, HDAC1, HDAC11 | HDAC8 8/4885HDAC3 4/4885HDAC1 2/4885 |
| US-12569563-B2 | Selective HDAC6 degraders and methods of use thereof | HDAC6, HDAC1, HDAC11 | HDAC8 9/4885HDAC3 4/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.