Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744913 | 0.96 | HDAC8 (0.61) | HDAC8CYP1A2CYP2C9ALDH1A1POLB | |
| SCHEMBL557990 | 0.85 | HDAC8 (0.60) | HDAC8L3MBTL1GAAHDAC3HDAC1 | |
| SCHEMBL25892570 | 0.84 | HDAC8 (0.50) | HDAC8CYP1A2CYP2C9ALDH1A1POLB | |
| SCHEMBL24881075 | 0.83 | HDAC8 (0.63) | HDAC8L3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL1066363 | 0.83 | HDAC8 (0.57) | HDAC8ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL31522340 | 0.83 | HDAC8 (0.67) | HDAC8CYP1A2CYP2C9ALDH1A1L3MBTL1 | |
| SCHEMBL1577613 | 0.83 | CYP1A2 (0.59) | HDAC8CYP1A2CYP2C9ALDH1A1L3MBTL1 | |
| SCHEMBL11913978 | 0.82 | ALDH1A1 (0.56) | ALDH1A1POLBL3MBTL1GAAMEN1 | |
| SCHEMBL1669619 | 0.81 | ALDH1A1 (0.70) | CYP1A2CYP2C9ALDH1A1POLBL3MBTL1 | |
| SCHEMBL11031322 | 0.81 | CYP1A2 (0.67) | HDAC8CYP1A2CYP2C9ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2015770-A2 | INSULIN DERIVATIVE | Novo Nordisk A/S (DK) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007128817-A2 | INSULIN DERIVATIVE | NOVO NORDISK A/S (DK) | 2007-11-15 | — | — | WO | disclosed |