Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | GPR4 | P46093 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29908969 | 0.89 | HDAC8 (0.57) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL24880999 | 0.85 | HDAC8 (0.61) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL29908950 | 0.84 | HDAC8 (0.51) | HDAC8HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL29908939 | 0.81 | HDAC8 (0.47) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL2227505 | 0.76 | HTR2C (0.41) | HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL18392619 | 0.75 | BCHE (0.43) | HDAC8CA1CA2BCHEACHE | |
| SCHEMBL24882016 | 0.75 | HDAC8 (0.53) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL29908940 | 0.74 | HDAC8 (0.56) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL24881075 | 0.74 | HDAC8 (0.63) | HDAC8HDAC3NCOR2CA1CA2 | |
| SCHEMBL24881437 | 0.74 | HDAC8 (0.58) | HDAC8HDAC3NCOR2HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4054607-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |