Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601358 | 1.00 | MAPT (0.39) | MAPTKDM4EABCG2PDE5ACSNK2A2 | |
| SCHEMBL23601392 | 0.91 | MAPT (0.37) | MAPTKDM4EABCG2PDE5ACSNK2A2 | |
| SCHEMBL23577177 | 0.88 | MAPT (0.37) | MAPTABCG2PDE5ACSNK2A2CSNK2B | |
| SCHEMBL23577209 | 0.79 | ABCG2 (0.38) | MAPTABCG2PDE5ACSNK2A2CSNK2B | |
| SCHEMBL23577123 | 0.78 | MAPT (0.33) | MAPTPTAFR | |
| SCHEMBL29909048 | 0.78 | MAPT (0.35) | MAPTKDM4EPTAFR | |
| SCHEMBL23578000 | 0.77 | ABCG2 (0.33) | ABCG2PDE5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL23578060 | 0.77 | RXFP1 (0.35) | MAPTABCG2PDE5ACSNK2A2CSNK2B | |
| SCHEMBL23601334 | 0.75 | IGF1R (0.32) | ABCG2PDE5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL29909273 | 0.75 | ABCG2 (0.36) | ABCG2PDE5ACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12054490-B2 | Diacylglycerol kinase modulating compounds | GILEAD SCIENCES, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12054490-B2 | Diacylglycerol kinase modulating compounds | DGKG, DGKB, DGKK | MAPT 4206/4885KDM4E 1748/4885ABCG2 4216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.