Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.65 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13001967 | 1.00 | KMT2A (0.67) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL23577148 | 0.89 | KCNK3 (0.82) | KMT2APOLBKCNK3KCNK9RAB9A | |
| SCHEMBL17013407 | 0.87 | KCNK3 (0.69) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL11316890 | 0.87 | PTGS1 (0.61) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL8374911 | 0.87 | HDAC1 (0.85) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL15998541 | 0.85 | HDAC1 (0.71) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL19829331 | 0.85 | MEN1 (0.67) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL2685329 | 0.84 | KCNK9 (0.67) | KMT2APOLBHDAC8HDAC6KCNK3 | |
| SCHEMBL8940247 | 0.84 | KCNK3 (0.72) | KMT2APOLBHDAC1HDAC2HDAC8 | |
| SCHEMBL7151866 | 0.84 | KMT2A (0.73) | KMT2APOLBHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12054490-B2 | Diacylglycerol kinase modulating compounds | GILEAD SCIENCES, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12054490-B2 | Diacylglycerol kinase modulating compounds | DGKG, DGKB, DGKK | KMT2A 2566/4885POLB 3027/4885HDAC1 1296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.