Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23576856 | 1.00 | NPC1 (0.41) | NPC1SMN1; SMN2MAPTDGAT1PLK1 | |
| SCHEMBL23577631 | 0.87 | NPC1 (0.41) | NPC1SMN1; SMN2MAPTPLK1 | |
| SCHEMBL29909038 | 0.87 | NPC1 (0.41) | NPC1SMN1; SMN2MAPTPLK1 | |
| SCHEMBL23601679 | 0.84 | NPC1 (0.51) | NPC1SMN1; SMN2MAPTPLK1TDO2 | |
| SCHEMBL29909739 | 0.84 | NPC1 (0.39) | NPC1SMN1; SMN2MAPT | |
| SCHEMBL23577842 | 0.84 | NPC1 (0.39) | NPC1SMN1; SMN2MAPT | |
| SCHEMBL27154315 | 0.73 | NPC1 (0.44) | NPC1MAPTDGAT1 | |
| SCHEMBL23576644 | 0.71 | NPC1 (0.41) | NPC1MAPTDGAT1 | |
| SCHEMBL29909620 | 0.71 | NPC1 (0.41) | NPC1MAPTDGAT1 | |
| SCHEMBL24668167 | 0.70 | NPC1 (0.42) | NPC1SMN1; SMN2MAPTDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4445902-A2 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2024-10-16 | — | — | EP | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |