Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23576644 | 1.00 | NPC1 (0.41) | NPC1CACNA2D1DGAT1MAPTALDH1A1 | |
| SCHEMBL23601680 | 0.88 | NPC1 (0.43) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29909113 | 0.83 | MAPT (0.44) | NPC1CACNA2D1DGAT1MAPTALDH1A1 | |
| SCHEMBL23577034 | 0.83 | MAPT (0.44) | NPC1CACNA2D1DGAT1MAPTALDH1A1 | |
| SCHEMBL23576960 | 0.83 | NPC1 (0.49) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11318534 | 0.83 | DGAT1 (0.39) | NPC1DGAT1MAPTALDH1A1MEN1 | |
| SCHEMBL30013472 | 0.83 | NPC1 (0.49) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29909270 | 0.82 | MAPT (0.43) | NPC1MAPTALDH1A1GAAMEN1 | |
| SCHEMBL23577291 | 0.82 | MAPT (0.43) | NPC1MAPTALDH1A1GAAMEN1 | |
| SCHEMBL29991937 | 0.78 | ATM (0.47) | NPC1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |