Sugi Predict

Sugi Predict / Compounds / SCHEMBL29909231

SCHEMBL29909231

SCHEMBL29909231

Fc1cc2c(Cl)nc(Cl)nc2cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.39
▸ GPR84 Q9NQS5 1/20 0.33
▸ APP P05067 1/20 0.31
▸ TXN P10599 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1748487 1.00 MAPT (0.39) MAPTGPR84APPTXNALDH1A1
SCHEMBL2541308 0.88 HTT (0.32) HTT
SCHEMBL29909463 0.88 HTT (0.32) HTT
SCHEMBL3668782 0.83 ACHE (0.39) MAPTALDH1A1HTT
SCHEMBL30013667 0.83 ACHE (0.39) MAPTALDH1A1HTT
SCHEMBL2170677 0.81 MAPT (0.37) MAPTGPR84
SCHEMBL29487315 0.81 HTT (0.35) HTT
SCHEMBL2724749 0.81 HTT (0.35) HTT
SCHEMBL25194733 0.77 HTT (0.35) HTT
SCHEMBL30504344 0.77 HTT (0.35) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 — — CN disclosed
CN-115362003-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2022-11-18 — — CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 — — EP disclosed