SCHEMBL29909627

SCHEMBL29909627

CN(c1cc(-c2ccc(C(C)(C)C)cc2)ccc1F)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
HRH4 Q9H3N8 1/20 0.33
MAT2A P31153 4/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
PTAFR P25105 2/20 0.32
CCR9 P51686 1/20 0.31
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30
SCN5A Q14524 1/20 0.30
PRMT5 O14744 2/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23576821 1.00 FNTA (0.35) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL23601026 0.87 HRH4 (0.33) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL31169447 0.87 HRH4 (0.33) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL29909419 0.85 FNTA (0.37) FNTAFNTBMAT2APTAFRCNR1
SCHEMBL23577547 0.85 FNTA (0.37) FNTAFNTBMAT2APTAFRCNR1
SCHEMBL23601034 0.85 MAT2A (0.35) HRH4MAT2AMEN1KMT2A
SCHEMBL29909086 0.85 FNTA (0.34) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL23577584 0.85 FNTA (0.34) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL23601759 0.85 FNTA (0.34) FNTAFNTBHRH4MAT2AMEN1
SCHEMBL23577059 0.85 FNTA (0.41) FNTAFNTBHRH4MAT2APTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed