Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331933 | 1.00 | NPC1 (0.34) | NPC1RAB9ACTSLCTSSCTSK | |
| SCHEMBL1332433 | 0.95 | MCHR1 (0.33) | MAPTSMN1; SMN2TP53KDM4EMEN1 | |
| SCHEMBL1333856 | 0.95 | MAPT (0.33) | CTSSRAF1MAPTKDM4EALDH1A1 | |
| SCHEMBL29910249 | 0.95 | MAPT (0.33) | CTSSRAF1MAPTKDM4EALDH1A1 | |
| SCHEMBL12573754 | 0.88 | MAPT (0.35) | NPC1RAB9ARAF1MAPTSMN1; SMN2 | |
| SCHEMBL1332426 | 0.88 | MAPT (0.35) | NPC1RAB9ARAF1MAPTSMN1; SMN2 | |
| SCHEMBL2019117 | 0.88 | FGFR1 (0.38) | BTKRAF1MAPK14RARBBRAF | |
| SCHEMBL12573758 | 0.88 | FGFR1 (0.38) | BTKRAF1MAPK14RARBBRAF | |
| SCHEMBL9968003 | 0.87 | FGFR1 (0.35) | BTKRAF1MAPTRARBBRAF | |
| SCHEMBL1332389 | 0.87 | FGFR1 (0.35) | BTKRAF1MAPTRARBBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895896-B1 | A PHOTOCHROMIC ARTICLE HAVING AT LEAST PARTIALLY CROSSED POLARIZED PHOTOCHROMIC-DICHROIC AND FIXED-POLARIZED LAYERS | TRANSITIONS OPTICAL INC (US) | 2022-11-02 | — | — | EP | disclosed |