⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23405304 | 1.00 | — | — | |
| SCHEMBL18571737 | 0.71 | AHR (0.35) | — | |
| SCHEMBL21061440 | 0.69 | — | — | |
| SCHEMBL29911268 | 0.68 | CYP2A6 (0.31) | — | |
| SCHEMBL23405180 | 0.68 | CYP2A6 (0.31) | — | |
| SCHEMBL23405203 | 0.66 | — | — | |
| SCHEMBL19031925 | 0.65 | ERN1 (0.32) | — | |
| SCHEMBL20641683 | 0.64 | KDM1A (0.32) | — | |
| SCHEMBL789434 | 0.64 | AHR (0.35) | — | |
| SCHEMBL17442670 | 0.62 | TTR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2024-04-09 | — | — | US | disclosed |
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2022-10-04 | — | — | US | disclosed |
| US-20220267339-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2022-08-25 | — | — | US | disclosed |