Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911596 | 0.95 | TGFBR1 (0.37) | TGFBR1HCRTR1HCRTR2ACVR1BRAF | |
| Formic Acid SCHEMBL30051928 | 0.93 | TGFBR1 (0.37) | TGFBR1HCRTR1HCRTR2ACVR1BRAF | |
| SCHEMBL30051471 | 0.84 | BRAF (0.41) | TGFBR1BRAFMAPK3MAPK1IRAK4 | |
| SCHEMBL29911530 | 0.81 | TGFBR1 (0.34) | TGFBR1ACVR1BRAFMAPK3MAPK1 | |
| SCHEMBL20086078 | 0.76 | IRAK4 (0.49) | HCRTR1HCRTR2IRAK4 | |
| SCHEMBL30052288 | 0.76 | JMJD6 (0.39) | TGFBR1HCRTR1HCRTR2IRAK4TGFBR2 | |
| SCHEMBL28976167 | 0.75 | TGFBR1 (0.42) | TGFBR1BRAFMAPK3MAPK1IRAK4 | |
| SCHEMBL29911649 | 0.75 | TGFBR1 (0.40) | TGFBR1HCRTR1MAPK1IRAK4TGFBR2 | |
| SCHEMBL29911772 | 0.75 | TGFBR1 (0.38) | TGFBR1HCRTR1HCRTR2BRAFMAPK3 | |
| SCHEMBL29911609 | 0.75 | IRAK4 (0.48) | TGFBR1ACVR1BRAFIRAK4TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115531387-A | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-12-30 | — | — | CN | claimed |
| CN-110234637-B | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-110234637-B | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | disclosed |