Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20086023 | 0.90 | IRAK4 (0.50) | IRAK4GRM4 | |
| SCHEMBL30051809 | 0.90 | IRAK4 (0.50) | IRAK4GRM4 | |
| SCHEMBL30062375 | 0.88 | MAPT (0.42) | IRAK4GRM4KMT2AGAAMAPT | |
| Formic Acid SCHEMBL29911885 | 0.88 | CTSA (0.41) | IRAK4FLT3GRM4KMT2A | |
| Formic Acid SCHEMBL28976193 | 0.87 | IRAK4 (0.47) | IRAK4GRM4 | |
| SCHEMBL30261674 | 0.86 | IRAK4 (0.41) | IRAK4PIM1PIM3PIM2FLT3 | |
| SCHEMBL20086057 | 0.86 | IRAK4 (0.41) | IRAK4PIM1PIM3PIM2FLT3 | |
| SCHEMBL20086025 | 0.85 | IRAK4 (0.53) | IRAK4CSNK1DMAP4K4EGFRFRK | |
| Formic Acid SCHEMBL30062335 | 0.85 | IRAK4 (0.40) | IRAK4GRM4KMT2AGAAMAPT | |
| SCHEMBL20086019 | 0.84 | IRAK4 (0.38) | IRAK4CSNK1DMAP4K4EGFRFRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115531387-A | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-12-30 | — | — | CN | claimed |
| CN-110234637-B | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115531387-A | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-110234637-B | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | disclosed |