SCHEMBL29912955

SCHEMBL29912955

Cn1c(-c2ccccc2)c(C(=O)O)c2nccnc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
CCNB2 O95067 1/20 0.42
CDK1 P06493 1/20 0.42
CCNB1 P14635 1/20 0.42
CDK5 Q00535 1/20 0.42
CDK5R1 Q15078 1/20 0.42
CCNB3 Q8WWL7 1/20 0.42
ALDH1A1 P00352 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NPC1 O15118 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
KDM4E B2RXH2 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6485737 1.00 CYP1A2 (0.42) CYP1A2CYP2C9CYP2C19CCNB2CDK1
SCHEMBL27157832 0.87 KDM5A (0.43) HTTKDM4EDHODHKMT2A
SCHEMBL29913098 0.87 KDM5A (0.43) HTTKDM4EDHODHKMT2A
SCHEMBL29913278 0.83 MAPT (0.38) MAPTHPGDDHODHKMT2A
SCHEMBL27157865 0.83 MAPT (0.38) MAPTHPGDDHODHKMT2A
SCHEMBL27158484 0.81 CYP1A2 (0.40) CYP1A2CYP2C9CYP2C19ALDH1A1KDM4E
SCHEMBL27158156 0.81 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL6477966 0.81 EGFR (0.51) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL6489316 0.81 ALDH1A1 (0.48) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL29913123 0.80 CYP1A2 (0.45) CYP1A2CYP2C9CYP2C19ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4415706-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF Vanqua Bio, Inc. (US) 2024-08-21 EP disclosed
EP-4329881-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF Vanqua Bio, Inc. (US) 2024-03-06 EP disclosed
CN-117642404-A Small molecule modulators of glucocerebrosidase activity and uses thereof 凡况生化公司 2024-03-01 CN disclosed
WO-2023064343-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF VANQUA BIO, INC. (US) 2023-04-20 WO disclosed
WO-2022232383-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF VANQUA BIO, INC. (US) 2022-11-03 WO disclosed