Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.69 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128671 | 1.00 | CRBN (0.69) | CRBNDDB1IKZF3BRD4PABPC1 | |
| SCHEMBL29568563 | 0.82 | CRBN (1.00) | CRBNDDB1IKZF3BRD4SMYD3 | |
| SCHEMBL20128668 | 0.82 | CRBN (1.00) | CRBNDDB1IKZF3BRD4SMYD3 | |
| SCHEMBL30760758 | 0.82 | CRBN (1.00) | CRBNDDB1IKZF3BRD4SMYD3 | |
| SCHEMBL30066328 | 0.82 | CRBN (1.00) | CRBNDDB1IKZF3BRD4SMYD3 | |
| SCHEMBL20128679 | 0.81 | CRBN (0.71) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL2241239 | 0.80 | RAB9A (0.49) | CRBNSMYD3 | |
| SCHEMBL10069143 | 0.80 | RAB9A (0.49) | CRBNSMYD3 | |
| SCHEMBL23799194 | 0.79 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20812186 | 0.79 | CRBN (0.68) | CRBNDDB1IKZF3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118638043-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-118059104-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-115175901-B | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4077309-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115175901-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2022-10-11 | — | — | CN | disclosed |