Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681095 | 1.00 | MAPK1 (0.54) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24681218 | 1.00 | MAPK1 (0.54) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL29914585 | 1.00 | MAPK1 (0.54) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24680718 | 1.00 | MAPK1 (0.54) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL29914587 | 0.92 | TGFBR1 (0.44) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL29914586 | 0.92 | TGFBR1 (0.44) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24681098 | 0.92 | TGFBR1 (0.44) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24681220 | 0.92 | TGFBR1 (0.44) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24681091 | 0.92 | TGFBR1 (0.44) | MAPK1LRRK2TGFBR1ACVR1FYN | |
| SCHEMBL24681107 | 0.91 | MAPK1 (0.48) | MAPK1LRRK2TGFBR1ACVR1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |