Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 5/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914391 | 1.00 | ACVR1 (0.41) | ACVR1TGFBR1RIPK2NOD2BMPR1B | |
| SCHEMBL24681618 | 1.00 | ACVR1 (0.41) | ACVR1TGFBR1RIPK2NOD2BMPR1B | |
| SCHEMBL29914621 | 0.83 | ACVR1 (0.41) | ACVR1TGFBR1RIPK2NOD2BMPR1B | |
| SCHEMBL24680790 | 0.83 | ACVR1 (0.41) | ACVR1TGFBR1RIPK2NOD2BMPR1B | |
| SCHEMBL29914435 | 0.83 | ACVR1 (0.41) | ACVR1TGFBR1RIPK2NOD2BMPR1B | |
| SCHEMBL27157872 | 0.83 | SYK (0.41) | SYKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL27157883 | 0.83 | SYK (0.41) | SYKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL27157857 | 0.83 | SYK (0.41) | SYKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24680772 | 0.78 | MAP3K12 (0.45) | ACVR1TGFBR1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL24681263 | 0.78 | MAP3K12 (0.45) | ACVR1TGFBR1BMPR1BBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |